Medical Research

1. Title: The Effects of Non-Thermal Pulsed  Electromagnetic Energy (Diapulse ®) on Wound Healing of Pressure Ulcers  in Spinal Cord-Injured Patients: A Randomized Double-Blind Study

Reseachers: C. Andrew Salzberg, MD,  Stephanie A. Cooper-Vastola, MD, Francisco J. Perez, MD, Maricela G.  Viehbeck, RN, BSN, ET, Daniel W. Byrne, MS

Publication: WOUNDS: A Compendium of Clinical Research and Practice, Volume 7, Number 1, January/February 1995

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2. Treating Cancer with Tumor Treating Fields (TED Talk)


3. Title: Low frequency and low intensity pulsed  electromagnetic field exerts its antiinflammatory effect through  restoration of plasma membrane calcium ATPase activity.

Researchers: Selvam R, Ganesan K, Narayana Raju KV, Gangadharan AC, Manohar BM, Puvanakrishnan R.

Publication: Life Sci. 2007 Jun 6;80(26):2403-10. Epub 2007 May 1.

Rheumatoid arthritis (RA) is a chronic inflammatory disorder affecting  1% of the population worldwide. Pulsed electromagnetic field (PEMF) has a  number of well-documented physiological effects on cells and tissues  including antiinflammatory effect. This study aims to explore the  antiinflammatory effect of PEMF and its possible mechanism of action in  amelioration of adjuvant induced arthritis (AIA). Arthritis was induced  by a single intradermal injection of heat killed Mycobacterium  tuberculosis at a concentration of 500 microg in 0.1 ml of paraffin oil  into the right hind paw of rats. The arthritic animals showed a biphasic  response regarding changes in the paw edema volume. During the chronic  phase of the disease, arthritic animals showed an elevated level of  lipid peroxides and depletion of antioxidant enzymes with significant  radiological and histological changes. Besides, plasma membrane Ca(2+)  ATPase (PMCA) activity was inhibited while intracellular Ca(2+) level as  well as prostaglandin E(2) levels was noticed to be elevated in blood  lymphocytes of arthritic rats. Exposure of arthritic rats to PEMF at 5  Hzx4 microT x 90 min, produced significant antiexudative effect  resulting in the restoration of the altered parameters. The  antiinflammatory effect could be partially mediated through the  stabilizing action of PEMF on membranes as reflected by the restoration  of PMCA and intracellular Ca(2+) levels in blood lymphocytes  subsequently inhibiting PGE(2) biosynthesis. The results of this study  indicated that PEMF could be developed as a potential therapy for RA in  human beings.

Link to research article 

4. Title: Electrochemical therapy of pelvic pain: effects of pulsed electromagnetic fields (PEMF) on tissue trauma.

Researchers: Jorgensen WA, Frome BM, Wallach C.

Publication: Eur J Surg Suppl. 1994;(574):83-6.

Unusually effective and long-lasting relief of pelvic pain of  gynaecological origin has been obtained consistently by short exposures  of affected areas to the application of a magnetic induction device  producing short, sharp, magnetic-field pulses of a minimal amplitude to  initiate the electrochemical phenomenon of electroporation within a 25  cm2 focal area. Treatments are short, fasting-acting, economical and in  many instances have obviated surgery. This report describes typical  cases such as dysmenorrhoea, endometriosis, ruptured ovarian cyst, acute  lower urinary tract infection, post-operative haematoma, and persistent  dyspareunia in which pulsed magnetic field treatment has not, in most  cases, been supplemented by analgesic medication. Of 17 female patients  presenting with a total of 20 episodes of pelvic pain, of which 11  episodes were acute, seven chronic and two acute as well as chronic, 16  patients representing 18 episodes (90%) experienced marked, even  dramatic relief, while two patients representing two episodes reported  less than complete pain relief.

Link to research article